White matter hyperintensities mediate the association between blood-brain barrier leakage and information processing speed
نویسندگان
چکیده
منابع مشابه
Do white matter hyperintensities mediate the association between brain iron deposition and cognitive abilities in older people?
BACKGROUND AND PURPOSE Several studies have reported associations between brain iron deposits (IDs), white matter hyperintensities (WMHs) and cognitive ability in older individuals. Whether the association between brain IDs and cognitive abilities in older people is mediated by or independent of total brain tissue damage represented by WMHs visible on structural magnetic resonance imaging (MRI)...
متن کاملWhite matter hyperintensities and normal-appearing white matter integrity in the aging brain
White matter hyperintensities (WMH) of presumed vascular origin are a common finding in brain magnetic resonance imaging of older individuals and contribute to cognitive and functional decline. It is unknown how WMH form, although white matter degeneration is characterized pathologically by demyelination, axonal loss, and rarefaction, often attributed to ischemia. Changes within normal-appearin...
متن کاملA general factor of brain white matter integrity predicts information processing speed in healthy older people.
Human white matter integrity has been related to information processing speed, but it is unknown whether impaired integrity results from localized processes or is a general property shared across white matter tracts. Based on diffusion MRI scans of 132 healthy individuals with a narrow age range around 72 years, the integrity of eight major white matter tracts was quantified using probabilistic...
متن کاملMTI of white matter hyperintensities.
The severity of tissue changes associated with incidental white matter hyperintensities (WMH) in the elderly cannot be sufficiently determined by conventional MRI. We, therefore, performed a regional analysis of the magnetization transfer ratio (MTR) maps obtained on a 1.5 T scanner from 198 neurologically asymptomatic participants of the Austrian Stroke Prevention Study (mean age 70, age range...
متن کاملWhite matter hyperintensities on brain magnetic resonance in systemic sclerosis.
OBJECTIVE To evaluate the brain status of patients with systemic sclerosis (SSc). METHODS Fourteen female patients with SSc aged 24-74, with a disease duration of 1-12 years and without other relevant systemic diseases, were enrolled. All patients and an age matched female control group (CG) of 14 clinically normal subjects, underwent brain magnetic resonance examination at 1.5 T; spin echo p...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neurobiology of Aging
سال: 2020
ISSN: 0197-4580
DOI: 10.1016/j.neurobiolaging.2019.09.017